TABLE 8.

Chemical structures of complexes 81–94 and IC₅₀ values of complexes toward different cell lines.

	Complex	R1	R2	λmax/nm of the LMCT band (N3→Pt)	λirr/nm	Cell line	IC50 (light)/μM	IC50 (dark)/μM	PI IC50 (dark)/IC50 (light)	Reference
	81		OH	260	465	A2780	11.7 ± 0.3	>100	>8.5	Shi et al. (2020b)
						A549	13.3 ± 0.7	>100	>7.5
						PC3	21.1 ± 0.4	>100	>4.7
						MRC5	—	>100	—
	82			308	465	A2780	1.3 ± 0.2	>50	>38.5	—
						A549	5.9 ± 0.6	>100	>16.9
						PC3	3.0 ± 0.1	>100	>33.3
						MRC5	—	>100	—
	83	OH		298	465	A2780	2.9 ± 0.2	>100	>34	Shi et al. (2020a)
						A549	7.8 ± 0.1	>100	>12
						MRC5	—	>100	—
	84	OH		297	465	A2780	0.92 ± 0.07	>100	>108	—
						A549	5.44 ± 0.05	>100	>18
						MRC5	—	>100	—
	85	OH		299	465	A2780	1.2 ± 0.2	>100	>83	—
						A549	6.6 ± 1.1	>100	>15
						MRC5	—	>100	—
	86			306	465	A2780	0.11 ± 0.02	1.9 ± 0.1	17.3
						A549	2.6 ± 0.3	>50	>19
						MRC5	—	>50	—
	87			313	465	A2780	0.15 ± 0.01	1.3 ± 0.2	8.7
						A549	1.2 ± 0.1	>20	>16
						MRC5	—	>20	—
	88			319	465	A2780	0.39 ± 0.01	1.9 ± 0.3	4.9
						A549	1.9 ± 0.1	>20	>10
						MRC5	—	>20	—
	89		OH	Around 300	420	A2780	2.7	>132.3	>49	Shaili et al. (2021)
						A2780cis	5.4	>199.8	>37
						OE19	8.2	>172.2	>21
						SK-MEL-28	15.5	175.2	11.3
						DU-145	20.0	176.0	8.8
	90		OH	Around 300	420	A2780	3.7	>162.8	>44	Shaili et al. (2021)
						A2780cis	4.0	>164.0	>41
						OE19	10.3	>154.5	>15
	91		OH	Around 300	420	A2780	13.4	>26.8	>2
						A2780cis	13.0	>26.0	>2
						OE19	17.5	>33.3	>1.9
	92		OH	306	—	—	—	—	—	—
	93		OH	279	465	A549	11.8 ± 0.1	>50	>4.2	—
						PC3	6.4 ± 0.7	>50	>7.5
	94		OH	296	465	A549	13.5 ± 1.3	>100	>7.4	—
						PC3	10.1 ± 0.2	>100	>9.9
						A2780	1.2 ± 0.1	>100	>83.3
					520	A549	92.8 ± 13.5	>100	>1.1
						PC3	32.7 ± 0.5	>100	>3.1
						A2780	35.3 ± 2.2	>100	>2.8
	95		—	Around 300	465	A2780	77.0 ± 2.9	>100	>1.3	Shi et al. (2018)
						A2780cis	29.5 ± 11.0	>100	>3.4
						OE19	36.2 ± 2.4	41.3 ± 3.2	1.1
						MRC5	>100	>100	—
	96		—	Around 300	465	A2780	33.9 ± 5.2	>100	>2.9	—
				Around 300	465	A2780cis	67.6 ± 15.7	>100	>1.5
				Around 300	465	OE19	27.5 ± 5.1	49.8 ± 1.5	1.8
				Around 300	465	MRC5	>100	>100	—
	97		—	Around 300	465	A2780	78.3 ± 6.8	>100	>1.3	—
				Around 300	465	A2780cis	35.5 ± 3.4	>100	>2.8
				Around 300	465	OE19	43.71.9	53.4 ± 0.4	1.2
				Around 300	465	MRC5	>100	>100	—
	98		—	Around 300	465	A2780	16.73.3	>100	>6.0	—
				A2780cis	17.0 ± 2.3	>100	>5.8
				OE19	8.8 ± 0.9	97.0 ± 5.7	11.0
				MRC5	>100	>100	—

The bold values represent the numbering of the complexes.