TABLE 2.
Univariate and multivariate Cox proportional hazards regression analyses in BC patients.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age | 1.032(1.018–1.047) | <0.001 | 1.033(1.019–1.048) | <0.001 |
| TNM stage | ||||
| I | Referent | — | Referent | — |
| II | 1.547 (0.881–2.716) | 0.129 | 1.609 (0.912–2.839) | 0.101 |
| III | 3.096 (1.733–5.533) | <0.001 | 3.375 (1.875–6.073) | <0.001 |
| Unknown | 7.337 (3.203–16.809) | <0.001 | 6.718 (2.835–15.918) | <0.001 |
| Tumor subtypes | ||||
| HR+/HER2- | Referent | — | Referent | — |
| HR+/HER2+ | 1.472 (0.837–2.589) | 0.179 | 1.53 (0.864–2.707) | 0.145 |
| HR-/HER2+ | 2.225 (0.952–5.201) | 0.065 | 1.49 (0.619–3.582) | 0.374 |
| TNBC | 1.588 (0.954–2.645) | 0.075 | 1.878 (1.123–3.142) | 0.016 |
| Unknown | 1.671 (1.074–2.6) | 0.023 | 1.341 (0.859–2.094) | 0.197 |
| ER status | ||||
| Negative | Referent | — | — | — |
| Positive | 0.767 (0.522–1.125) | 0.175 | — | — |
| Unknown | 1.781 (0.788–4.024) | 0.165 | — | — |
| PR status | ||||
| Negative | Referent | — | — | |
| Positive | 0.813 (0.568–1.163) | 0.258 | — | — |
| Unknown | 1.842 (0.828–4.099) | 0.134 | — | — |
| HER2 status | ||||
| Negative | Referent | — | — | |
| Positive | 1.447 (0.895–2.338) | 0.131 | — | — |
| Unknown | 1.502 (0.992–2.275) | 0.055 | — | — |
| YTHDF3 | 1.028 (1.009–1.047) | 0.003 | 1.02 (1–1.04) | 0.047 |