Table I.
Particle size and ζ-potential of DDAB-based cationic liposomes and small interfering RNA lipoplexes.
| Liposome | Lipoplexb | |||||
|---|---|---|---|---|---|---|
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|
|
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| Liposome | Sizea, nm | PDI | ζ-potentiala, mV | Sizea, nm | PDI | ζ-potentiala, mV |
| LP-DDAB/DSPE | 101.9±0.9 | 0.24±0.01 | 46.9±1.8 | 152.1±3.2 | 0.24±0.01 | 38.7±1.4 |
| LP-DDAB/DPPE | 108.1±1.5 | 0.22±0.01 | 44.7±0.3 | 209.2±5.5 | 0.29±0.01 | 40.2±1.4 |
| LP-DDAB/DMPE | 111.2±2.6 | 0.23±0.01 | 47.3±0.3 | 167.6±1.4 | 0.18±0.01 | 43.8±2.1 |
| LP-DDAB/DOPE | 103.0±1.3 | 0.21±0.01 | 52.2±1.2 | 181.0±4.7 | 0.17±0.02 | 47.1±1.1 |
| LP-DDAB/POPE | 99.6±1.0 | 0.21±0.01 | 46.2±0.7 | 190.2±2.6 | 0.21±0.01 | 42.3±1.7 |
| LP-DDAB/DSPC | 132.4±2.0 | 0.23±0.01 | 45.9±0.7 | Aggregation | ND | ND |
| LP-DDAB/DPPC | 123.1±1.4 | 0.23±0.01 | 47.8±1.7 | 149.7±0.6 | 0.20±0.01 | 41.9±3.0 |
| LP-DDAB/DMPC | 106.7±2.3 | 0.23±0.01 | 45.9±0.2 | 158.1±5.8 | 0.20±0.01 | 37.5±2.0 |
| LP-DDAB/DOPC | 120.0±1.3 | 0.27±0.00 | 45.1±1.8 | 169.3±2.6 | 0.21±0.00 | 40.2±1.8 |
| LP-DDAB/POPC | 110.2±5.4 | 0.20±0.06 | 45.5±4.8 | 178.3±17.7 | 0.17±0.07 | 35.7±0.2 |
Aggregation indicates particle size >1 µm.
In water.
Charge ratio (+:-) of cationic lipid to siRNA phosphate, 4:1. Data are presented as the mean ± SD (n=3). PDI, polydispersity index; ND, not determined; DDAB, dimethyldioctadecylammonium bromide; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine; DPPE, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; DMPE, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; POPE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine; LP, liposome.