Table II.
Particle size and ζ-potential of DOTAP-based cationic liposomes and small interfering RNA lipoplexes.
| Liposome | Lipoplexb | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Liposome | Sizea, nm | PDI | ζ-potentiala, mV | Sizea, nm | PDI | ζ-potentiala, mV |
| LP-DOTAP/DSPE | 111.8±2.0 | 0.23±0.01 | 50.3±0.5 | 216.3±27.3 | 0.19±0.07 | 48.7±2.7 |
| LP-DOTAP/DPPE | 116.0±0.9 | 0.20±0.01 | 48.3±0.7 | 163.7±6.5 | 0.21±0.01 | 41.1±0.7 |
| LP-DOTAP/DMPE | 113.7±1.8 | 0.28±0.01 | 52.4±2.2 | 184.0±5.6 | 0.20±0.01 | 47.8±2.2 |
| LP-DOTAP/DOPE | 109.2±1.0 | 0.21±0.01 | 53.7±1.6 | 179.1±5.7 | 0.16±0.01 | 42.8±1.5 |
| LP-DOTAP/POPE | 111.7±1.4 | 0.24±0.02 | 49.6±1.0 | 175.8±6.5 | 0.21±0.01 | 40.3±0.4 |
| LP-DOTAP/DSPC | 93.3±0.8 | 0.22±0.01 | 48.9±1.4 | 228.7±1.5 | 0.26±0.00 | 32.2±0.7 |
| LP-DOTAP/DPPC | 112.8±0.8 | 0.26±0.00 | 46.7±0.7 | 200.8±2.8 | 0.23±0.00 | 26.6±2.8 |
| LP-DOTAP/DMPC | 107.2±1.0 | 0.25±0.00 | 46.3±2.7 | 240.5±1.9 | 0.28±0.02 | 31.3±1.1 |
| LP-DOTAP/DOPC | 102.2±0.9 | 0.24±0.01 | 48.6±3.0 | 227.3±4.1 | 0.25±0.00 | 35.2±0.1 |
| LP-DOTAP/POPC | 115.5±2.0 | 0.26±0.01 | 46.0±1.6 | 233.1±3.0 | 0.28±0.01 | 31.3±0.6 |
In water.
Charge ratio (+:-) of cationic lipid to siRNA phosphate, 4:1. Data are presented as the mean ± SD (n=3). DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane methyl sulfate salt; PDI, polydispersity index; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine; DPPE, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; DMPE, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; POPE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine; LP, liposome.