Table 1.

Office of the National Coordinator List of High-Priority Drug-Drug Interactions

	Drug A	Drug B
1.	Amphetamine & Derivatives	MAOIs
2.	Atazanavir	PPIs
3.	Febuxostat	Azathioprine & Mercaptopurine
4.	SSRIs	MAOIs
5.	Irinotecan	Strong CYP3A4 Inhibitors
6.	Narcotic Analgesics	MAOIsa
7.	Tricyclic Antidepressants	MAOIs
8.	High-risk QT Prolonging Agents	High-risk QT Prolonging Agents
9.	Ramelteon	Strong CYP1A2 Inhibitors
10.	Strong CYP3A4 Inducers	Protease Inhibitors
11.	HMG Co-A Reductase Inhibitors	CYP3A4 & Protease Inhibitors
12.	CYP3A4 & Protease Inhibitors	Ergot Alkaloids & Derivatives
13.	Tizanidine	CYP1A2 Inhibitors
14.	Tranylcypromine	Procarbazine
15.	Triptans	MAOIs

Abbreviations: MAOI, monoamine oxidase inhibitor; SSRI, selective serotonin reuptake inhibitor; CYP3A4, cytochrome P450 isozyme 3A4; CYP1A2, cytochrome P450 isozyme 1A2; PPI, proton pump inhibitor.