Table 2.

Clinical characteristics of patients with CNV changes and no history of malignancy before mNGS testing.

No.	Sex, year	History of malignancy	Diagnosis of admission	Diagnosis of discharge	Symptom	Prior antimicrobial agents use	Onco-mNGS		Conventional method
							Pathogen detected	CNVs	Culture result	Pathology detected
1	Female, 58	None	Thoracic vertebrae lesion	Diffuse large B cell lymphoma	Chest and back pain	Vancomycin; Fosfomycin	None	Multiple Chrsa Del/Dup	None	Bone biopsy: diffuse large B cell lymphoma
2	Male, 67	None	Liver abscess	Lung cancer; Liver occupation; Pneumonia	Fever; Change in metal status	Meropenem; Ciprofloxacin; Linezolid;	None	Chr2 Dup	None	Bronchoscope: neoplasm in superior segmental bronchus Pathology: adenocarcinoma
3	Male, 23	None	Fever of unknown origin	NK T cell lymphoma	Fever; Vomit	Meropenem; Doxycycline; Vancomycin; Cefoperazone; Sulbactam	Blood: Bacillus thuringiensis	Multiple Chrs Del/Dup	None	Bone marrow smear: NK T cell lymphoma
4	Female, 71	None	Lung lesion	Lung cancer	Cough; Sputum	None	None	Multiple Chrs Del/Dup	None	Lung biopsy: adenocarcinoma
5	Male, 71	None	Pericardial and pleural effusion	Lung cancer	None	Moxifloxacin	None	Multiple Chrs Del/Dup	None	Lung biopsy: adenocarcinoma
6	Male, 69	None	Encephalitis possible	Central lymphoma possible	Fever; Change in metal status	Ceftriaxone; Metronidazole	CSF: Elizabethkingia anophelis	Chr9q Dup	None	–

^aChr, chromosome; Dup, duplication; Del, deletion.