TABLE 2.

Summary of miRNAs involved in the pathogenesis of schistosomiasis.

MiR-name	Target genes	Pathways	Function	References
Let-7b	TβRI	TGF-β/SMAD signaling pathway	Anti-fibrosis	Tang et al., 2017
MiR-21	SMAD7	TGF-β/SMAD and IL-13/STAT6 signaling pathways	Pro-fibrosis	Kong et al., 2019
MiR-27b	PPARγ	TGF-β signaling pathway	Pro-fibrosis	Zhu et al., 2018a
MiR-92a-2-5p	TLR2	Unstudied	Anti-fibrosis	Zhao et al., 2019
MiR-96	SMAD7	TGF-β/SMAD signaling pathway	Pro-fibrosis	Luo et al., 2018
MiR-130a-3p	MAPK1, TβRI, TβRII	TGF-β and MAPK signaling pathways	Anti-fibrosis	Liu et al., 2021
MiR-146a/b	STAT1	IFN-γ signaling pathway	Macrophage transformation	He et al., 2016
MiR-155	FOXO3a	ERK1 signaling pathway	Pro-fibrosis	Zhu et al., 2018b
MiR-181a	TLR4	TLR4 receptor signaling pathway	Anti-fibrosis	Tang et al., 2021
MiR-182	FOXO1	PI3K/AKT signaling pathway	Pro-fibrosis	Huang et al., 2018
MiR-200a	TGF-β2	TGF-β signaling pathway	Anti-fibrosis	Xu et al., 2021
MiR-203-3p	SMAD3	SMAD signaling pathway	Anti-fibrosis	He et al., 2018b
MiR-351	VDR	SMAD and IFN-γ signaling pathways	Pro-fibrosis	He et al., 2018a
MiR-454	SMAD4	SMAD signaling pathway	Anti-fibrosis	Zhu et al., 2014
Sja-miR-1	SFRP1	Wnt/β-catenin pathway	Pro-fibrosis	Wang Y. et al., 2020
Sja-miR-71a	SEMA4D, FZD4	TGF-β/SMAD and IL-13/STAT6 signaling pathways	Anti-fibrosis	Wang L. et al., 2020; Jiang et al., 2022
Sja-miR-125b, Sja-bantam	PROS1, FAM212B, CLMP	Unstudied	Macrophage proliferation	Liu et al., 2019
Sja-miR-2162	TβRIII	TGF-β/SMAD signaling pathway	Pro-inflammatory, Pro-fibrosis	He et al., 2020
Sja-miR-3096	PIK3C2A	Unstudied	Tumor suppressor	Lin et al., 2019