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Flowchart summarizing the NCT03877809 Sirthalaclin clinical trial and the key analysis presented in this study. Five patients concluded the trial at V8 (180 days), as indicated. HbF and excess of free α-globin chains were analyzed using HPLC. Content of γ-globin mRNA was analyzed using RT-qPCR. The scheme of the trial has been described elsewhere. 46
