. Author manuscript; available in PMC: 2022 Jun 23.

Published in final edited form as: Obstet Gynecol. 2019 Mar;133(3):468–475. doi: 10.1097/AOG.0000000000003115

Table 1.

Characteristics of Included Studies Examining the Effect of 17α-Hydroxyprogesterone Caproate on Glucose Intolerance and Rate of Gestational Diabetes Mellitus

	Gyamfi et al¹²	Nelson et al⁵	Rebarber et al¹⁰	Rouholamin et al¹³	Waters et al¹¹	Wolfe et al¹⁴
Study type	Secondary analysis of 2 RCTs	Prospective cohort	Retrospective cohort	RCT	Retrospective cohort	Prospective cohort study
Study country	United States	United States	United States	Iran	United States	United States
Sample size	441	1,720	2,081	164	440	207
17α-OHPC dose (mg/wk)	250	250	250	250	250	250
Control group	No 17 α -OHPC	No 17 α -OHPC	No 17 α -OHPC	No 17 α -OHPC	No 17 α -OHPC	No 17 α -OHPC
Gestational age at 17 α -OHPC initiation (wk)	16–20	16–20	16–20	16–20	16–20	16–20
OGTT testing algorithm	Criteria for diagnosis of GDM not predefined^*	1-h, 50-g test; GDM diagnosis with 100-mg, 3-h test	1-h, 50-g test; GDM diagnosis with 100-mg, 3-h test	1-h, 50-g test; GDM diagnosis with 100-mg, 3-h test	1-h, 50-g test; GDM diagnosis with 100-mg, 3-h test	1-h, 50-g test; GDM diagnosis with 100-mg, 3-h test
Inclusion criteria	Singleton, history of prior PTB at less than 36 wk	Singleton, history of prior PTB at less than 35 wk	Singleton, history of prior PTB at less than 37 wk	Singleton, history of prior PTB at less than 37 wk	Singleton, history of prior PTB at less than 37 wk	Singleton, history of prior PTB at less than 37 wk
Exclusion criteria	Multiple gestation, pregestational DM, unknown GDM diagnosis, lost to follow-up	Multiple gestation, pregnancy induced hypertension, placental abruption	Multiple gestation, pregestational DM, unknown GDM	Multiple gestation, BMI greater than 30, abnormal OGTT, family history of DM, unknown GDM	Multiple gestation, pregestational DM, unknown GDM	Multiple gestation, progestational diabetes, unknown GDM, younger than 18 or older than 50 y.

RCT, randomized controlled trial; 17 α -OHPC, 17 α-hydroxyprogesterone caproate; OGTT, oral glucose tolerance test; GDM, gestational diabetes mellitus; PTB, preterm birth; BMI, body mass index; DM, diabetes mellitus.

Because this is a secondary analysis, criteria for diagnosis of GDM were not predefined. However, the centers that participated in the original study used similar guidelines to diagnose GDM.