. 2022 Jun 22;7(8):817–824. doi: 10.1001/jamacardio.2022.1651

Table 2. Summary of Results Comparing Changes From Baseline to After Rehabilitation.

Outcome	Complete case analysis								Multiple imputation, difference in changes (early CR − usual-care CR)^a
	No.		Mean (SD)				Difference (early CR − usual-care CR) in changes^a		Mean (95% CI)	P value
	UCR	ECR	Usual-care CR		Early CR		Mean (95% CI)	P value
	UCR	ECR	Baseline	After CR	Baseline	After CR	Mean (95% CI)	P value
6MWT, m	57	61	243.9 (144.2)	491.4 (92.9)^b	209.1 (117.6)	484.1 (95.9)^b	27.5 (−11.2 to 66.2)	.16	27.7 (−9.9 to 65.3)	.15
5T-STS	55	58	19.27 (10.26)	9.33 (2.45)^b	18.42 (9.50)	9.07 (2.45)^b	−0.58 (−3.84 to 2.67)	.72	−0.57 (−3.56 to 2.42)	.71
Leg strength, kg	48	52	32.04 (13.17)	37.26 (13.89)^b	33.72 (11.51)	40.92 (13.71)^b	1.97 (−1.90 to 5.84)	.32	1.12 (−2.62 to 4.87)	.55
Grip strength, kg	56	59	32.48 (9.01)	36.42 (9.27)^b	32.17 (8.93)	35.01 (10.14)^b	−1.10 (−3.16 to 0.96)	.29	−0.98 (−3.02 to 1.07)	.35
GAD-7	44	55	5.18 (5.24)	1.55 (3.34)^b	5.95 (5.47)	1.35 (2.23)^b	0.96 (−0.99 to 2.92)	.33	1.00 (−0.81 to 2.81)	.28
PHQ-9	54	61	7.87 (5.64)	2.22 (3.00)^b	8.39 (5.78)	2.44 (3.05)^b	0.30 (−1.86 to 2.47)	.78	0.70 (−1.30 to 2.70)	.49
SF-12
Physical	37	47	12.03 (3.08)	16.38 (2.28)^b	11.51 (3.03)	15.53 (2.39)^b	−0.33 (−1.66 to 1.00)	.62	−0.71 (−1.88 to 0.46)	.24
Mental	37	47	19.00 (4.55)	22.30 (3.74)^b	17.74 (3.93)	22.57 (3.00)^b	1.53 (−0.24 to 3.30)	.09	0.65 (−0.95 to 2.26)	.43
SF-12 total	37	47	31.03 (7.01)	38.84 (5.26)^b	29.47 (6.28)	38.09 (4.47)^b	0.81 (−1.84 to 3.46)	.55	−0.39 (−2.73 to 1.95)	.75

Abbreviations: 5T-STS, 5 Times Sit-to-Stand Test; 6MWT, 6-minute walk test; CR, cardiac rehabilitation; ECR, early CR; GAD-7, Generalized Anxiety Disorder questionnaire; PHQ-9, Patient Health Questionnaire; SF-12, 12-Item Short-Form Survey; UCR, usual-care CR.

^{^a}

Positive and negative differences favor early CR and usual-care CR, respectively.

^{^b}

Improvement.