. Author manuscript; available in PMC: 2022 Jun 23.

Published in final edited form as: ACS Infect Dis. 2020 Jan 13;6(2):205–214. doi: 10.1021/acsinfecdis.9b00203

Table 3.

IC₅₀ values for concentration-dependent inhibition of parasite proliferation in indicated strains by PfENT1 inhibiting compounds. Average IC₅₀ values are from three independent trials.

IC₅₀ values for concentration-dependent inhibition of proliferation in strains by compounds (μM)
Compound	WT	HB3 (F36S/V129I)	7G8 (Q284E)	ART^R
1	34 ± 2	23 ± 5	16 ± 0.2	29 ± 11
2	33 ± 8	17 ± 1^*	9 ± 0.2^**	12 ± 4^**
3	21 ± 2	12 ± 2^**	19 ± 0.8	7 ± 2^***
4	14 ± 0.5	10 ± 2	3 ± 0.2^**	8 ± 2
5	36 ± 0.2	31 ± 0.7	15 ± 1^***	18 ± 5^***
6	32 ± 0.9	23 ± 4	12 ± 0.8^**	13 ± 4^**
7	45 ± 2	24 ± 2^**	12 ± 1^***	19 ± 7^**
13	7 ± 0.1	5 ± 0.9	4 ± 0.2^*	3 ± 0.9^**
19	45 ± 1	21 ± 5^***	12 ± 2^****	13 ± 3^***

Data show mean ± SEM. WT IC₅₀ values are republished with permission from Frame et al., 2015.¹⁴ Significantly different than WT by one-way ANOVA,

(p ≤ 0.05),

^**

(p ≤ 0.01),

^***

(p ≤ 0.001),

^****

(p ≤ 0.0001).