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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Curr Protoc. 2022 Jun;2(6):e459. doi: 10.1002/cpz1.459

Figure 1.

Figure 1.

Comparisons of heavy chain antibody, single domain antibody with conventional IgG. Human and mouse antibodies have both heavy and light chains. Camel and shark have heavy chain only antibody and the variable domain of them are so called single domain antibodies. VL: variable domain of light chain; CL: constant domain of light chain; VH: variable domain of heavy chain; CH (1,2,3,4,5): constant domain of heavy chain (1,2,3,4,5); VHH: Camelid variable region of the heavy chain only antibody; VNAR: Antigen binding variable domain of the shark immunoglobulin new antigen receptor.