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. 2022 Jun 10;7(24):20441–20456. doi: 10.1021/acsomega.2c01833

Table 2. Recent in Vivo Studies on Improving Iron Bioavailability.

technique compound study system food results reference
encapsulation iron encapsulated in banana peel matrix animal bioassay (rat) tempeh A significant (p < 0.05) increase was observed in serum hemoglobin and iron levels in all groups with the highest value found in an iron matrix dose of 20 ppm. (137)
iron and folic acid (FA) bovine serum albumin nanoparticles animal bioassay (rat) stirred functional yogurt Enhancement in the levels of hemoglobin, iron, ferritin, and total protein was observed. (138)
microencapsulated liposomal iron pyrophosphate human trial iron pyrophosphate sachets Microencapsulated liposomal iron pyrophosphate sachets showed higher palatability and bioavailability. (145)
Serum hemoglobin levels in nonpregnant women of reproductive age were significantly increased.
lipoosomal iron human trial oral liposomal iron 62% of the patients who completed the treatment responded to oral liposomal iron therapy (mean increases of hemoglobin from 11.4 to 12.6 g/dL). (146)
Number of patients with mild iron deficiency was decreased.
chelation tripeptide iron complex, ferrous glycinate animal bioassay (rat) - Blood parameters such as hemoglobin, serum ferritin, and transferrin levels as well as growth parameters and mRNA expression which is a marker of iron deficiency showed that the tripeptide iron complex was more efficient than FeSO4 or the ferrous glycinate complex in alleviating IDA. (154)
desalted duck egg white peptides-ferrous chelate animal bioassay (rat) - In iron-deficient rats, 3 weeks of treatment caused red blood cells, serum ferritin, hemoglobin, and serum iron levels to reach the normal levels. (152)
The effects of IDA were reduced more efficiently by desalted duck egg white peptide-ferrous chelate compared to FeSO4.
whey protein concentrate–iron complex animal bioassay (rat) - In regular weaning and anemic conditions, the WPC–Fe complex supplementation improves iron bioavailability, hemoglobin level, percent apparent digestibility coefficient, and percent retention/intake. (161)
In iron-deficient animals, a spray-dried WPC–Fe complex supplementation significantly increased iron digestion and metabolism.
nanoparticulation ferric hydroxide-polyphosphate nanoparticles animal bioassay (rat) - Relative iron bioavailability from polyP-FeO NPs was greater by ∼170% relative to FeSO4. (168)
bio iron(II) nanoparticles animal bioassay (rat) yogurt Bioiron nanoparticles were good sources of bioavailable iron. (169)
Bioiron nanoparticles in 200 and 400 μg/mL were safe and enhanced yogurt quality and shelf life.
β-lactoglobulin fibril iron nanoparticles animal bioassay (rat) - β-Lactoglobulin fibril iron nanoparticles were digestible and bioavailable without altering the organoleptic features of the food carriers. (170)
β-Lactoglobulin fibril nanocomposites showed no toxicity in a rat assay.