. 2022 Jun 22;10:90. doi: 10.1186/s40478-022-01388-7

Table 1.

Patient characteristics, BioFINDER cohort

	Control	PD	PDD	MSA	PSP	Controls that converted to LBD
Number	47	50	14	15	15	2
αSyn RT-QuIC positive (%)	8 (17%)	47 (94%)	14 (100%)	5 (33%)	5 (33%)	2 (100%)
Sex Female/Male (% Female)	27/20 (57%)	25/25 (50%)	6/8 (43%)	6/9 (40%)	8/7 (53%)	1/1 (50%)
Age in years	66.6 (8.9)	68.0 (6.9)	71.1 (6.2)	66.6 (6.6)	72.3 (5.5) ^{c, d, i}	65.0 (4.2)
MMSE	28.7 (1.3)	28.9 (1.3)	21.9 (3.8)^{c, d}	27.3 (2.9)^{e, f}	24.8 (4.8)^{c, d}	28.5 (2.1)^h
Disease Duration in years	NA	6.8 (3.8)	16.8 (6.9)^d	6.9 (2.7)^f	6.8 (3.8)^f	NA
UPDRS III	1.9 (2.7)	13.1 (7.9)^a	38.4 (11.0)^{a, d}	44.5 (17.5)^{a, d}	47.5 (14.3)^{a, d}	0.5 (0.7)^{e, h, i, j}
Hoehn & Yahr	NA	2.1 (0.6)	3.3 (0.7)^d	4.1 (0.89) ^{d, h}	4.3 (0.7) ^{d, g}	0 (0)^{e, h, I, j}

Control

PDD

MSA

PSP

Controls that converted to LBD

Number

αSyn RT-QuIC positive (%)

(17%)

(94%)

(100%)

(33%)

(100%)

Sex Female/Male

(% Female)

27/20

(57%)

25/25

(50%)

6/8

(43%)

6/9

(40%)

8/7

(53%)

1/1

(50%)

Age in years

66.6 (8.9)

68.0 (6.9)

71.1

(6.2)

66.6

(6.6)

72.3

(5.5) ^{c, d, i}

65.0

(4.2)

MMSE

28.7

(1.3)

28.9

(1.3)

21.9

(3.8)^{c, d}

27.3

(2.9)^{e, f}

24.8

(4.8)^{c, d}

28.5

(2.1)^h

Disease Duration in years

6.8 (3.8)

16.8 (6.9)^d

6.9

(2.7)^f

6.8

(3.8)^f

UPDRS III

1.9

(2.7)

13.1

(7.9)^a

38.4

(11.0)^{a, d}

44.5

(17.5)^{a, d}

47.5

(14.3)^{a, d}

0.5

(0.7)^{e, h, i, j}

Hoehn & Yahr

2.1

(0.6)

3.3

(0.7)^d

4.1

(0.89) ^{d, h}

4.3

(0.7) ^{d, g}

(0)^{e, h, I, j}

Data is given as mean and standard deviation (SD) except for in dichotomized values. Significances were analyzed using Mann–Whitney or in the case of dichotomized values Chi-square. a) p < 0.001 vs. control; b) p < 0.01 vs. control; c) p < 0.05 vs. control; d) p < 0.001 vs. PD; e) p < 0.05 vs. PD; f) p < 0.001 vs. PDD; g) p < 0.01 vs. PDD; h) p < 0.05 vs. PDD) i: p < 0.05 vs. MSA; j) p > 0.05 vs. PSP