Table 2.
Patient characteristics, AZSAND/BBDP cohort
| αSyn RT-QuIC positive | αSyn RT-QuIC negative | p-value | |
|---|---|---|---|
| Number | 41 | 60 | |
| Age at death, Mean (SD) | 83 (7.0) | 86 (8.6) | 0.002 |
| Sex Male/Female | 31/10 | 35/25 | 0.073 |
| Lewy Body positive | 38 (93%) | 10 (17%) | < 0.001 |
|
Lewy Body density total score (max 40) Mean (SD) |
21 (11) 1 missing |
1.05 (2.9) | < 0.001 |
| Lewy Body stage | |||
| 0 | 3 | 50 | |
| I (olfactory bulb only) | 1 | 2 | |
| IIa (brainstem predominant) | 2 | 3 | |
| IIb (limbic predominant) | 7 | 4 | |
| III (brainstem/limbic) | 16 | 1 | |
| IV (neocortical) | 12 | 0 | |
|
Total senile plaque density score (0–15) Mean (SD) |
8.05 (6.19) | 7.16 (6.25) | p = 0.427 |
| Total neurofibrillary tangle density score (0–15), Mean (SD) | 7.70 (3.73) | 6.95 (2.94) | p = 0.703 |
| TDP-43 pathology Yes/No (missing) | 3/10 (28) | 7/18 (35) | p = 0.744 |
Significances are calculated using Mann–Whitney (continuous and ordinal variables) or chi2 (dichotomized variables). P < 0.05 was considered statistically significant and is given in bold