Table 3.
Distribution of neuropathological diagnosis in the (AZSAND/BBDP) cohort
| Diagnostic category NP diagnosis |
N | αSyn RT-QuIC positive | αSyn RT-QuIC negative | Sensitivity | Specificity |
|---|---|---|---|---|---|
| Standard LBD | 25 | 25 | 100% | ||
| DLB-AD | 4 | 4 | 100% | ||
| PD | 16 | 16 | 100% | ||
| PD-AD | 4 | 4 | 100% | ||
| PD-PSP* | 1 | 1 | 100% | ||
| Non-standard LBD | 23 | 13 | 10 | 57% | |
| ADLB | 14 | 9 | 5 | 64% | |
| ILBD | 4 | 2 | 2 | 50% | |
| LBS-PSP | 1 | 1 | 0% | ||
| LBS-VaD | 2 | 2 | 0% | ||
| LBS-VaD-PSP ** | 1 | 1 | 100% | ||
| LBS-Astrocytoma | 1 | 1 | 100% | ||
| Lewy Body negative | 53 | 3 | 50 | 94% | |
| PSP | 2 | 1 | 1 | 50% | |
| PSP-AD | 2 | 2 | 100% | ||
| VaD-CBD | 1 | 1 | 100% | ||
| MSA | 1 | 1 | 100% | ||
| AD | 7 | 2 | 5 | 71% | |
| VaD-AD | 7 | 7 | 100% | ||
| Controls | 25 | 25 | 100% | ||
| Other | 8 | 8 | 100% |
*Included as PD in statistical analyses
**Microscopic changes of PSP, not included as clinicopathological PSP in statistical analyses. Abbreviations: AD = Alzheimers disease; ADLB = Alzheimer’s disease with Lewy bodies, not meeting criteria for DLB;
CBD = Corticobasal degeneration; DLB = Dementia with Lewy Bodies; LBS = Lewy Bodies, LBD = Lewy Body Disorders; ILBD = Incidental Lewy Body Disease; VaD = Vascular dementia; MSA = Multiple System Atrophy; PSP = Supranuclear Palsy
Bold is for total Standard LBD/Non-standard LBD/Lewy body negative