Table 1.

The discovery lacunar stroke PWAS identified 7 significant genes, of which 5 were found in the confirmation PWAS, and all 4 replicated

			Discovery PWAS			Confirmation PWAS		Evidence for replication
	Gene	Chromosome	PWAS z-score	PWAS P	PWAS FDR P	PWAS z-score	PWAS P
1	CAND2	3	−4.281	1.86E−05	1.36E−02	−4.334	1.46E−05	Yes
2	ICA1L	2	−5.136	2.81E−07	4.11E−04	−4.213	2.52E−05	Yes
3	ALDH2	12	3.871	1.09E−04	3.98E−02	3.567	3.61E−04	Yes
4	MADD	11	3.770	1.63E−04	3.98E−02	2.917	3.53E−03	Yes
5	MRVI1	11	−3.776	1.60E−04	3.98E−02	−1.680	9.30E−02	-
6	CSPG4a	15	3.696	2.19E−04	4.58E−02	-	-
7	PTPN11a	12	−3.884	1.03E−04	3.98E−02	-	-

This table gives the z-scores for the lacunar stroke PWAS associations with their corresponding P values and FDR-adjusted P values for all significant genes in the lacunar stroke discovery PWAS. Confirmation lacunar stroke PWAS z-scores and their corresponding unadjusted P values are provided for the significant genes in the discovery lacunar stroke PWAS

^aProtein not profiled in the confirmation proteomic dataset