Table 3.

Summary of the 3 lacunar stroke PWAS-significant genes with evidence for being consistent with a causal role in lacunar stroke

	Gene	Chromosome	Discovery PWAS	Confirmation PWAS	Confirmation MR	Evidence for causality	TWAS significant
						COLOC
1	ICA1L	2	Significant	Replicated	Replicated	Yes	Yes
2	CAND2*	3	Significant	Replicated	Replicated	Yes	N/A
3	ALDH2*	12	Significant	Replicated	Replicated	Yes	No

N/A, refers to genes that did not have significant heritability estimates to be included in the TWAS of lacunar stroke

*New gene refers to genes not within a 1-Mb window of SNPs with P < 5.23 × 10⁻⁸ identified in Taylor et al. lacunar stroke GWAS