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. 2022 Jun 23;19:43. doi: 10.1186/s12989-022-00482-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — PM_2.5-induced vascular remodeling, pulmonary inflammation, and IL-6 and OPN secretion was reduced in mice with low AhR affinity. The B6 and B6.D2 mice were aspirated with 25 μg of PM_2.5 twice weekly for 12 weeks. A neutrophil numbers, B OPN protein in BALF, C IL-6 protein in BALF, and D OPN protein concentrations in plasma were determined. E Lung sections were stained with H&E. The arrow indicates the lesions of vascular remodeling. Scale bar, 200 μm. F The B6 mice was aspirated with 25 μg of PM_2.5 twice weekly for 12 weeks. H&E; SMA staining; IHC staining of OPN; and IHC staining of IL-6. Arrows indicate small arteries. Scale bar, 30 μm. Each value represents the mean ± SD of ten mice. *P < 0.05 for comparison with the control-treated mice (n = 10, one-way ANOVA); ^#P < 0.05 for comparison between B6 and B6.D2 mice (n = 10, two-way ANOVA)