Table 3.

Summary results for regression models predicting gestational age at delivery and offspring birth weight using epigenetic age acceleration^a

Outcome	Predictor	Std. β	Std. 95% CI	Test statistic	P value
Gestational age	DNAmAge	0.02	− 0.10–0.13	0.32	0.748
	Senescent T-cells	0.04	− 0.08 – 0.15	0.66	0.51
	DNAmIEAA	0.02	− 0.09–0.14	0.4	0.687
	DNAmEEAA	− 0.01	− 0.12–0.11	− 0.12	0.901
	DNAmPhenoAge	− 0.02	− 0.14–0.09	− 0.35	0.726
	DNAmGrimAge	− 0.04	− 0.15–0.08	− 0.62	0.539
	DNAmADM	− 0.08	− 0.20–0.03	− 1.4	0.163
	DNAmB2M	− 0.03	− 0.14–0.09	− 0.44	0.657
	DNAmCystatinC	− 0.05	− 0.17–0.06	− 0.88	0.378
	DNAmGDF15	0.01	− 0.11–0.12	0.13	0.899
	DNAmLeptin	− 0.15	− 0.26–− 0.04	− 2.63	0.009
	DNAmPackYears	− 0.02	− 0.13–0.10	− 0.26	0.797
	DNAmPAI1	0.03	− 0.09–0.15	0.46	0.643
	DNAmTIMP1	0.00	− 0.11–0.12	0.06	0.951
	DNAmTL	− 0.05	− 0.16–0.07	− 0.82	0.411
Postnatal weight	DNAmAge	0.02	− 0.09–0.12	0.3	0.765
	Senescent T-cells	0.05	− 0.06–0.16	0.89	0.375
	DNAmIEAA	0.04	− 0.06–0.15	0.82	0.415
	DNAmEEAA	− 0.07	− 0.18–0.04	− 1.31	0.192
	DNAmPhenoAge	− 0.03	− 0.14–0.08	− 0.55	0.582
	DNAmGrimAge	0.08	− 0.03–0.19	1.42	0.155
	DNAmADM	0.09	− 0.02–0.20	1.64	0.102
	DNAmB2M	− 0.02	− 0.12–0.09	− 0.31	0.757
	DNAmCystatinC	0.03	− 0.07–0.14	0.63	0.532
	DNAmGDF15	0.01	− 0.10–0.12	0.23	0.819
	DNAmLeptin	0.04	− 0.07–0.15	0.74	0.461
	DNAmPackYears	0.06	− 0.05–0.17	1.09	0.278
	DNAmPAI1	0.01	− 0.11–0.12	0.09	0.929
	DNAmTIMP1	0.04	− 0.07–0.15	0.71	0.479
	DNAmTL	0.05	− 0.06–0.16	0.96	0.339

^aAll models adjust for maternal age (are age acceleration measures), offspring sex, composite socioeconomic score, and the mother’s pre-pregnancy BMI; models predicting birth weight also adjust for gestational age at delivery and postnatal age of anthropometry measurement