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. 2022 Jun 23;21:135. doi: 10.1186/s12943-022-01600-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circEXOC6B inhibits the growth of CRC cells in vitro and in vivo. A The expression of circEXOC6B in SW620 and HCT116 after transfected with siRNAs or a circEXOC6B overexpression vector. B CCK8 and C EdU assays indicated that the lower circEXOC6B levels promoted the proliferation of CRC cells while the higher circEXOC6B levels inhibited the proliferation. Scale: 50 μm. D Colony formation assay demonstrated that knockdown of circEXOC6B expression promoted the clonogenicity of SW620 and HCT116 while overexpression of circEXOC6B suppressed cancer cell clonogenicity. E Flow cytometry showed that the decreased circEXOC6B levels reduced the 5-FU-induced apoptosis of CRC cells, whereas the elevated circEXOC6B levels had the opposite effect