Table 3.
Table of pairwise comparisons of power spectra values before and 1 day immediately after injection: (a) pairwise comparisons of power spectra values of delta, theta and gamma power values before and after injection, (b) pairwise comparisons of phase-amplitude coupling of Theta 2-High Gamma modulation indices before and after injection
| Frequency band | Pairwise comparison | Estimate | SE | df | T ratio | P value |
|---|---|---|---|---|---|---|
| (a) Post hoc pairwie contrasts of hippocampal power spectra values, pre and post injection | ||||||
| Delta | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.4741 | 0.1503 | 784 | − 3.1544 | 3.4965E−03 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.5309 | 0.1556 | 784 | − 3.4128 | 1.5923E−03 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.4224 | 0.1640 | 784 | − 2.5759 | 1.8642E−02 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 0.6009 | 0.1455 | 784 | − 4.1293 | 1.2635E−04 | |
| Theta 1 | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.4105 | 0.1366 | 784 | − 3.0043 | 5.2680E−03 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.5427 | 0.1414 | 784 | − 3.8369 | 2.9373E−04 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.4037 | 0.1491 | 784 | − 2.7070 | 1.2703E−02 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 0.7166 | 0.1323 | 784 | − 5.4157 | 3.0870E−07 | |
| Theta 2 | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.4686 | 0.1565 | 784 | − 2.9942 | 6.1932E−03 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.5905 | 0.1620 | 784 | − 3.6450 | 8.0361E−04 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.3546 | 0.1707 | 784 | − 2.0771 | 6.5286E−02 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 0.8470 | 0.1515 | 784 | − 5.5896 | 2.9056E−07 | |
| Low Gamma | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.7983 | 0.1343 | 784 | − 5.9449 | 1.9928E−08 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.5682 | 0.1390 | 784 | − 4.0874 | 1.2294E−04 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.6172 | 0.1463 | 784 | − 4.2191 | 7.2208E−05 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 1.1232 | 0.1300 | 784 | − 8.6379 | 6.2262E−16 | |
| High Gamma | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.7792 | 0.1133 | 784 | − 6.8783 | 1.8638E−10 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.5535 | 0.1173 | 784 | − 4.7206 | 1.1868E−05 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.5450 | 0.1236 | 784 | − 4.4108 | 4.2871E−05 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 0.9976 | 0.1097 | 784 | − 9.0956 | 9.0178E−17 | |
| (b) Post hoc pairwise contrasts of Theta2-High gamma coupling in hippocampus of tau-seeded mice, pre- and post-injection | ||||||
| Hippocampus | 3mo NL-G-F-Tau Post–3mo NL-G-F-Tau Pre | − 0.0003 | 0.0001 | 3492 | − 3.6237 | 1.4275E−03 |
| 6mo NL-G-F-Tau Post–6mo NL-G-F-Tau Pre | − 0.0003 | 0.0001 | 3492 | − 3.1300 | 6.5037E−03 | |
| 3mo NL-NL-Tau Post–3mo NL-NL-Tau Pre | − 0.0003 | 0.0001 | 3492 | − 3.2444 | 4.6307E−03 | |
| 6mo NL-NL-Tau Post–6mo NL-NL-Tau Pre | − 0.0003 | 0.0001 | 3492 | − 2.9325 | 1.1000E−02 | |
Pre refers to pre-injection values, post refers to post-injection values. SE refers to standard error. Df refers to degrees of freedom. Estimate refers to the estimated difference in value between pairwise comparisons