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Nrf2 activation in different tissues.
| Activation of the heart | Activation of blood vessels | Activation of skeletal muscles | |
|---|---|---|---|
| Increase in luminal stress (Pathway A) | √ | ||
| Increase in oxidative stress (Pathway B) | √ | √ | √ |
| Hypoxia (Pathway C) | √ | √ | √ |
| Heat stress (Pathway D) | √ | ||
| Increase in AMPK (Pathway E) | √ | √ | √ |
