Table 1.
Histidine kinases, pHis phosphatases and their substrates
| Histidine kinases | Substrates |
|---|---|
| NME1 | ACLY, Gβ1 |
| NME2 | Gβ1, KCa3.1, TRPV5 |
| Histone H4 kinase | Histone H4 |
| Bacterial TCS His kinases (e.g. CheA, NRii, EnvZ) | CheY, NRI, OmpR |
| pHis phosphatases | |
| PHPT1 | pACLY, pGβ1, pKCa3.1, pTRPV5 |
| LHPP | ? |
| PGAM5 | pNME2 |
| PP1, PP2A, PP2C | pHistone H4 |
| pHis enzyme intermediates | Intermediate pHis isoform |
| 6-phosphfructo-2-kinase bisphosphatase | 3-pHis |
| Phosphoglycerate mutase 1 | 3-pHis |
| Acid phosphatase | 3-pHis |
| STS-1, STS-2, PGAM5 phosphatases | 3-pHis |
| Succinyl-CoA synthetase | 3-pHis |
| Phospholipase D | 3-pHis |
| Tyrosyl DNA phosphodiesterase 1 | 3-pHis |
| Glucose-6-phosphatase | 3-pHis |
| NAMPT | 1-pHis |
| NME1–9 | 1-pHis |
| Bacterial TCS His kinases | 1-pHis or 3-pHis |