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. 2022 Jun 23;93(4):948–952. doi: 10.1038/s41390-022-02163-z

Fig. 4. ACE2 and TMPRSS2 protein content in type II alveolar cells.

Fig. 4

a Percentage of subjects with ACE2 and b TMPRSS2 immunostaining intensity from +1 to +3 in type II alveolar cells of lung parenchyma of children (Ch), adults below 60 years of age (< 60) and adults 60 years of age and older (≥ 60). Children did not display +3 intensity of staining for both ACE2 and TMPRSS2. Lung parenchymal samples from children (1 to 18 years of age, n = 21), adult subjects between 20 and 60 years of age (n = 26) and subjects 60 years of age and older (n = 29) were analysed. Representative images of surgically resected lung tissue stained for ACE2 or TMPRSS2 protein (red, as indicated by black arrows) and AT2 cells (brown) counterstained with haematoxylin (blue). Brown cells are TTF1-positive cells. Scale bar: 20 µm. * P < 0.0001 when compared to < 60 and ≥ 60 (Kruskal–Wallis).