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. 2022 Jun 9;13:862709. doi: 10.3389/fphar.2022.862709

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Copyright © 2022 He, Wang, Yang, Ma, Qin, Yan, Rong, Xie, Li, Si, Li and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nar down-regulated the expression of core target VEGFA and PI3K/Akt/CREB5 signaling pathway. (A) Western blot detected the protein expression of VEGFA. (B) Analysis of VEGFA protein expression. (C) Analysis of VEGFA mRNA expression. (D,E) Nar suppressed KDR, p-Src, p-PI3K, p-Akt and CREB5 expression which upregulated by HG group. (F) Bar graph showed related protein expression analysis. ^* p < 0.05, ^** p < 0.01 compared with Control group, ^# p < 0.05, ^## p < 0.01 compared with HG group.