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. Author manuscript; available in PMC: 2022 Jun 23.
Published in final edited form as: Cell Rep. 2022 May 31;39(9):110877. doi: 10.1016/j.celrep.2022.110877

Figure 4. AP-1 TFs collaborate with neuronal TFs to select LRG enhancers.

Figure 4.

(A) Top-ranked Gene Ontology terms enriched in cell-type-specific enhancers with GREAT analysis; complete list in Table S7.

(B) LRG enhancers in Glu and GABA neurons are enriched for LRGs.

(C) Motif enrichment within late-inducible ATAC-seq peaks.

(D) Expression of DLX family genes. DLX2 and DLX5 proteins are detected in GABA neurons but not Glu neurons. Box center, median; box, 25th to 75th percentiles; whiskers, minima and maxima. Scale bar, 50 μm.

(E) Motif histogram plots of Glu (left) and GABA (right) neuron late-inducible CREs centered over AP-1 binding motif.

(F) Read density aggregate plots of FOS-bound peaks centered over ATAC-seq summits before and after stimulation.

(G) Position weight matrices of top motifs enriched in FOS-bound inducible peaks in Glu (purple) and GABA (orange) neurons. The ratios indicate the proportion of peaks containing respective motifs compared to a guanine-cytosine-matched background set of genomic regions.

See also Tables S3 and S4.