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. 2022 Jun 9;9:870269. doi: 10.3389/fmed.2022.870269

Table 3.

The nonsynonymus mutations in non-FV deficiency patient population.

Exon refGene AAChange Frequency SNP
exon25 T6673C X2225Q 0.00128 Stoploss
exon25 A6665G D2222G 0.02046 Nonsynonymoussnv
exon24 A6452G K2151R 0.00128 Nonsynonymoussnv
exon23 C6298T R2100C 0.00128 Nonsynonymoussnv
exon23 G6277A G2093R 0.00128 Nonsynonymoussnv
exon20 G5828C G1943A 0.00128 Nonsynonymoussnv
exon17 G5558T G1853V 0.01918 Nonsynonymoussnv
exon17 A5552C E1851A 0.00128 Nonsynonymoussnv
exon17 A5431T M1811L 0.00128 Nonsynonymoussnv
exon16 G5378T R1793I 0.00128 Nonsynonymoussnv
exon16 A5290G M1764V 0.23402 Nonsynonymoussnv
exon16 G5275C D1759H 0.00128 Nonsynonymoussnv
exon13 C4210T P1404S 0.12276 Nonsynonymoussnv
exon13 C4189T L1397F 0.67008 Nonsynonymoussnv
exon13 T4000C F1334L 0.00128 Nonsynonymoussnv
exon13 A3980G H1327R 0.02174 Nonsynonymoussnv
exon13 C3853A L1285I 0.09335 Nonsynonymoussnv
exon13 C3446T S1149F 0.00384 Nonsynonymoussnv
exon13 A2998G K1000E 0.00128 Nonsynonymoussnv
exon13 T2911C W971R 0.00128 Nonsynonymoussnv
exon13 A2773G K925E 0.21228 Nonsynonymoussnv
exon13 A2594G H865R 0.21228 Nonsynonymoussnv
exon13 A2573G K858R 0.21228 Nonsynonymoussnv
exon13 A2450C N817T 0.02174 Nonsynonymoussnv
exon13 G2219A R740Q 0.00128 Nonsynonymoussnv
exon13 A2032G K678E 0.00384 Nonsynonymoussnv
exon10 A1601G Q534R 1 Nonsynonymoussnv
exon10 G1538A R513K 0.66624 Nonsynonymoussnv
exon11 T1699C C567R 0.00128 Nonsynonymoussnv
exon8 T1238C M413T 0.02558 Nonsynonymoussnv
exon7 C1106T A369V 0.00512 Nonsynonymoussnv
exon7 A1000G R334G 0.00256 Nonsynonymoussnv
exon6 C801A F267L 0.00128 Nonsynonymoussnv
exon4 T398C F133S 0.00128 Nonsynonymoussnv

Among these nonsynoymous mutations, 8 of them marked in red have high (exon16: M1764V exon13: P1404S, L1397F, K925E, H865R, K858R; exon10:Q534R, R513K) in whole-exome sequencing of OSCC tumor-normal (fresh-frozen tumors and matched whole blood) database in Taiwan.