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. 2022 Jun 18;11(6):930. doi: 10.3390/biology11060930

Figure 7.

Figure 7

Tpz-1 (0.19 µM) disrupts spindle formation and polarity in HeLa cells undergoing mitosis. (a) Tpz-1, (b) 1% v/v DMSO, (c) 1 µM Paclitaxel, and (d) 5 µg/mL Cytochalasin-D treated cells were stained with α-tubulin-Alexa-488 (microtubules), phalloidin-Alexa-568 (microfilaments), and DAPI (nucleus) prior to examination by confocal microscopy. DMSO was included as vehicle control, and Paclitaxel and Cytochalasin-D as microtubule and microfilament disruptive agents, respectively. Only cells undergoing mitosis were imaged.