Figure 2.

Nrf2 response to oxidative stress. Under an oxidative environment, Keap1 releases Nrf2, which translocates from the cytoplasm to the nucleus, where it binds to the ARE sequence, activating the anti-inflammatory response elements (ARE) pathway. This pathway allows for the transcription of genes that code for the main antioxidant enzymes, which will modulate mitochondrial damage by decreasing ROS and facilitating ATP synthesis. HO-1: heme oxygenase-1. NQO1: H quinone oxidoreductase-1. GST: glutathione S-transferase. GCL: glutamate-cysteine ligase. GPx: glutathione peroxidase. This figure was created in Biorender.