Figure 3.

The ROCK inhibitor study was conducted independently by two reviewers according to the screening criteria. The studies were selected in the following order: (1) Duplicate articles were excluded. (2) Those with unrelated titles were excluded. Subsequently, (3) those with unrelated abstracts were excluded, and the exclusion considerations for the abstracts were as follows: only traditional medicine, herb extracts, alkaloids, and flavonoids. No dementia model animal or patient. No cognition assessment. No ROCK inhibitors. No clinical trials. (4) The following text was checked to exclude articles that did not study the effect of ROCK inhibitors on behavioral experiments. (5) Studies included in the quantitative synthesis. (6) Finally, only studies using the Morris water maze were left.