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Aberrantly activated oncogenes deregulate the import of glucose through Glut1 into cancer cells. The solid purple arrows depict the metabolites and metabolic reactions. Dashed arrows depict regulatory effects of signal transduction components. Legend: Glut1, glucose transporter 1; HK, hexokinase; GLS1, glutaminase 1; PRPS2, phosphoribosyl pyrophosphate synthetase 2; CAD, carbamoyl-phosphate synthetase 2; RTK, receptor for tyrosine kinase; ASCT2/SN2, glutamine transporter gene.
