Table 3.
Summary of regression analysis of models.
| Response | Suggested | Model Equations in Terms of Important Coded Factors | Model Sequential p-Value |
R2 | Adjusted R2 | Predicted R2 | Adequate Precision |
|---|---|---|---|---|---|---|---|
| Particle size | Linear | −0.0000005672 × A + 0.000009104 × B − 0.000001001 × C | <0.001 | 0.9593 | 0.9742 | 0.8746 | 21.608 |
| PDI | Mean | +0.1149 | <0.0001 | 0 | 0 | −0.1378 | N/A |
| EE | 2F1 | +0.5153 + 0.0811 × A − 0.0454 × B + 0.0200 × C − 0.0382 × AC − 0.0421 × BC | 0.0003 | 0.9761 | 0.9641 | 0.9289 | 30.0192 |
| D/L ratio | Linear | +0.1530 + 0.0269 × A + 0.0454 × C | <0.0001 | 0.9422 | 0.9333 | 0.9178 | 32.559 |
| Stability | Quadratic | +0.8486 + 0.0058 × A − 0.0218 × B + 0.0014 × C + 0.0333 × AC − 0.0265 × B2 | 0.0024 | 0.9582 | 0.9372 | 0.8570 | 21.9604 |
| Normalized drug release | Linear | +2.70 + 0.5558 × A − 0.3800 × B − 0.0777 × C − 0.3292 × AB + 0.3340 × AC | <0.0001 | 0.9695 | 0.9542 | 0.9075 | 30.4475 |