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. 2022 May 30;10(6):1274. doi: 10.3390/biomedicines10061274

Figure 1.

Figure 1

Cx3cr1Cre-ert2-YFPRxrαflox/flox mice show reduced expression of Rxrα in blood monocytes, which has no impact on PB parameters. (A) Study design (created with BioRender.com); (B) Rxrα wildtype allele and Rxrα L- allele expression in PB and different tissues of Cx3cr1ΔRxrα and control mice assessed by PCR and gel electrophoresis; (C) comparison of blood monocyte Rxrα expression between Cx3cr1ΔRxrα and control mice; (D) analysis of different blood parameters in Cx3cr1ΔRxrα and control mice. Arb: arbitrary; BM: bone marrow; CCR2: C-C chemokine receptor type 2; control (+/+): control mice [littermates with a floxed Rxrα allele but without Cre expression]; Cx3cr1ΔRxrα (Cre/+): mice with a floxed Rxrα allele and Cre expression; CyK: cytokine; ELP: electrophoresis; FACS: Fluorescence activated cell sorting; I/R injury: Ischemia/Reperfusion injury; mac: macrophage; mo: monocyte; PB: peripheral blood; PET: positron emission tomography; Rxr: Retinoid X receptor; qPCR: real-time polymerase chain reaction.