Table 1.
Characteristics of ICU patients with candidemia in the three candidemia cohorts.
| Variables | Pre-COVID-19 Cohorts | COVID-19 Cohort | p-Value | |
|---|---|---|---|---|
| 2005–2008 n = 66 |
2012–2015 n = 77 |
2019–2021 n = 62 |
||
| Age, median (IQR) | 67 (21) | 63 (31) | 69 (15.8) | 0.001 |
| males, n (%) | 45 (68.1) | 46 (59.7) | 45 (72.4) | 0.27 |
| APACHE II score on ICU admission, median (IQR) | 19 (8.8) | 20 (10) | 15 (7) | <0.001 |
| SOFA score on ICU admission, median (IQR) | 9 (4) | 10 (5) | 8 (3) | 0.001 |
| SOFA score on candidemia day, median (IQR) | 8.5 (6) | 7 (5) | 11 (6) | 0.001 |
| Delta SOFA score, median (IQR) | 0 (4) | −1 (3.5) | 3 (6) | <0.001 |
| ICU admission diagnosis Medical, n (%) Surgical, n (%) |
22 (33) 44 (66.7) |
40 (53.3) 35 (46.7) |
62 (100) 0 (0) |
<0.001 |
| Co-morbidities Diabetes mellitus, n (%) Current malignancy, n (%) |
5 (7.6) 6 (9.1) |
3 (3.9) 5 (6.5) |
16 (25.8) 5 (8.1) |
<0.001 0.99 |
| Hospital stay before candidemia onset, days, median (IQR) | 24 (18) | 30 (41.8) | 28.5 (19.5) | 0.15 |
| ICU stay before candidemia onset, days, median (IQR) | 15.5 (19.8) | 25 (34.5) | 22 (18.2) | 0.69 |
| ICU length of stay, days, median (IQR) | 35.5 (34.5) | 49 (51) | 34.5 (39.8) | 0.029 |
| Presence of shock on candidemia day, n (%) | 34 (52.3) | 30 (46.1) | 45 (75) | 0.001 |
| Incidence of candidemia, (%) | 3.8 | 4.2 | 10.3 | <0.001 |
| Mortality, n (%) | 42 (63.6) | 35 (46.7) | 35 (56.5) | 0.92 |
ICU, intensive care unit; IQR, interquartile range; APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment; Delta SOFA, SOFA score on candidemia day minus SOFA score on ICU admission.