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The sialic acid metabolic pathway. The schematic shows the different enzymes involved and each step’s respective localization. Feedback inhibition by CMP-Neu5Ac on GNE is also shown. The CMAH that biosynthesizes Neu5Gc is highlighted in green (CMAH). The pathway is modified from the REACTOME sialic metabolic pathway [25]. Created with BioRender.com (accessed on 9 March 2022).
