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Pigs act as a “mixing vessel” between avian species and humans. Pig possesses both α2-3 and α2-6 linkage and also the two main Sia structures (Neu5Gc and Neu5Ac). Pigs act as a “mixing vessel” between avian species and humans for influenza viruses. Gene swapping can occur in pigs between avian, swine, and human viruses, which can result in the evolution of a novel virus that could lead to pandemics in humans.
