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The involvement of Htt in normal vesicular transport and role of mHtt in impaired vesicular transport in HD. Under normal conditions, HTT interacts with the motor proteins dynactin, dynein, and kinesin and recruits GADPH to supply the necessary ATP. In HD, mHtt aggregates sequester GAPDH and motor proteins, and phosphorylates kinesin. Furthermore, microtubules are acetylated by mHtt, which hinders binding of kinesin-1 to the microtubules.
