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Top: Illustration of the identified inflammatory states (PC1–PC4) and their main contributing blood markers (inflammation: TNF-α, TNF-R1, TNF-R2, IL1-β, IL4, IL6, IL8, IL10; Oxidative Stress: NO, NEO; Anti-oxidant: TAC; DNA damage: GUA, MDA) in middle-age (left) and older-age (right) participants. Bottom: Significant associations (Bonferroni-corrected) between the identified inflammatory states (PC1–PC4) and AD biomarkers in middle-age (left) and older-age (right) participants.
