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. 2022 Jun 7;11(6):874. doi: 10.3390/biology11060874

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Wild−type and reversed Mrap2a/b differently affect the pharmacological profiles of zMc4r. (A–C) Dose−responsive stimulation of MC4R by α−MSH−induced cAMP production with different ratios of wild-type and reversed Mrap2a/b (A,B) or MRAP2 (C). (D–F) Dose−responsive inhibition of MC4R by antagonist SHU9119 with different ratios of wild-type and reversed Mrap2a/b (D,E) or MRAP2 (F). (G–I) The basal cAMP level caused by transfected MC4R, MRAP2 and RMRAP2 in the absence of an agonist. Data were analyzed by one−way ANOVA and shown as mean ± SEM of three replicates. ns (not significant difference), * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001. 2a: Mrap2a, R2a: RMrap2a, 2b: Mrap2b, R2b: RMrap2b, M2: MRAP2, RM2: RMRAP2.