Table 3.
Multivariable conditional logistic regression analysis focused on the association between FQ use and FQ resistance in E. coli over a 12–month period (dose-response effect).
| Variables | Adjusted OR (95%CI) | p |
|---|---|---|
| FQ prescription in previous year 0 |
Ref. |
Ref. |
| 1 | 2.40 (1.62–3.56) | <0.0001 |
| 2 | 2.76 (1.63–4.66) | <0.0001 |
| 3+ | 4.21 (2.38–7.50) | <0.0001 |
| At least one other J01 prescription in previous year | 1.10 (0.83–1.45) | 0.516 |
| Age | 1.11 a (1.03–1.20) | 0.008 |
| Gender | 1.39 (1.05–1.84) | 0.010 |
| Hospitalization days | 1.03 b (1.01–1.06) | 0.020 |
| Diagnosis of chronic diseases Diabetes |
1.40 (1.02–1.93) | 0.037 |
| COPD | 1.46 (1.09–1.96) | 0.004 |
a OR calculated for 10-year increments; b OR calculated for 10-day increments. Abbreviations: FQ = fluoroquinolone, COPD = Chronic obstructive pulmonary disease.