Figure 2.

Most represented MoA of RUNX1 promoting IR in NAFLD in the population of TPMS model solutions. Gene names are used in the representations. RUNX1, runt-related protein 1; HDA1C, histone deacetylase 1; PTGS2, prostaglandin G/H synthase 2; c-Jun, protein encoded by JUN gene; TNF, tumour necrosis factor; NFκB, nuclear factor kappa B; IL6, interleukin 6; LCN2, neutrophil gelatinase-associated lipocalin 2; CEBPA, CCAAT/enhancer-binding protein beta; SOCS3, suppressor of cytokine signaling 3; PKC, protein kinase C; JNK1, c-Jun N-terminal kinase 1; MTOR, mammalian target of rapamycin serine/threonine-protein kinase; IRS, insulin receptor substrate. This picture was generated using Graphviz software.