Table 3.
Lipotoxicity and fibrosis effector proteins modulated when RUNX1 is activated.
| Gene Name | Protein Name | Causative Effect in NAFLD | Activation by RUNX1 |
|---|---|---|---|
| LIPOTOXICITY | |||
| JNK1 | c-Jun N-terminal kinase 1 | 1 | 0.999 |
| CEBPB | CCAAT/enhancer-binding protein beta | 1 | 0.825 |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | 1 | 0.819 |
| MAP3K7 | Transforming growth factor beta-activated kinase 1/Mitogen-activated protein kinase 7 | 1 | 0.722 |
| NOS2 | Nitric oxide synthase, inducible | 1 | 0.667 |
| MTOR | Serine/threonine-protein kinase mTOR | 1 | 0.617 |
| LCN2 | Neutrophil gelatinase-associated lipocalin | 1 | 0.609 |
| PLIN1 | Perilipin-1 | 1 | 0.563 |
| HMOX1 | Heme oxygenase 1 | 1 | 0.490 |
| MAP3K5 | Apoptosis signal-regulating kinase 1/mitogen-activated protein kinase 5 | 1 | 0.460 |
| PPARG | Peroxisome proliferator-activated receptor gamma | 1 | 0.402 |
| XBP1 | X-box-binding protein 1 | 1 | 0.327 |
| UCP2 | Mitochondrial uncoupling protein 2 | 1 | 0.183 |
| ACC1 | Acetyl-CoA carboxylase 1 | 1 | 0.113 |
| ADIPOR2 | Adiponectin receptor protein 2 | −1 | −0.600 |
| ADIPOR1 | Adiponectin receptor protein 1 | −1 | −0.633 |
| SIRT1 | Sirtuin 1 | −1 | −0.780 |
| FIBROSIS | |||
| SMAD3 | Mothers against decapentaplegic homolog 3 | 1 | 0.859 |
| ANGPT2 | Angiopoietin-2 | 1 | 0.854 |
| BAX | Apoptosis regulator BAX | 1 | 0.839 |
| AGTR1 | Type-1 angiotensin II receptor | 1 | 0.839 |
| TGFB1 | Transforming growth factor beta-1 | 1 | 0.827 |
| IL1B | Interleukin-1 beta | 1 | 0.693 |
| IL8 | Interleukin-8 | 1 | 0.683 |
| MMP9 | Matrix metalloproteinase-9 | 1 | 0.614 |
| FAS | Tumor necrosis factor receptor superfamily member 6 | 1 | 0.518 |
| MMP2 | 72 kDa type IV collagenase | 1 | 0.508 |
| CTGF | Connective tissue growth factor | 1 | 0.497 |
| CASP1 | Caspase-1 | 1 | 0.472 |
| NLRP3 | NACHT, LRR and PYD domains-containing protein 3 | 1 | 0.352 |
| AGT | Angiotensinogen | 1 | 0.340 |
| SPP1 | Osteopontin | 1 | 0.330 |
| TIMP1 | Metalloproteinase inhibitor 1 | 1 | 0.282 |
| MYD88 | Myeloid differentiation primary response protein MyD88 | 1 | 0.277 |
| PDGFA | Platelet-derived growth factor subunit A | 1 | 0.248 |
| LY96 | Lymphocyte antigen 96 | 1 | 0.224 |
| COL1A1 | Collagen alpha-1(I) chain | 1 | 0.209 |
| COL1A2 | Collagen alpha-2(I) chain | 1 | 0.124 |
| NR1H4 | Bile acid receptor | −1 | −0.441 |
| PTEN | Phosphatase and tensin homolog | −1 | −0.958 |
| LIPOTOXICITY AND FIBROSIS | |||
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit | 1 | 0.999 |
| NOX1 | NADPH oxidase 1 | 1 | 0.894 |
| NOX4 | NADPH oxidase 4 | 1 | 0.822 |
| CCL2 | C-C motif chemokine 2 | 1 | 0.813 |
| TNF | Tumor necrosis factor | 1 | 0.812 |
| CYBB | Cytochrome b-245 heavy chain | 1 | 0.640 |
| NFKB2 | Nuclear factor NF-kappa-B p100 subunit | 1 | 0.535 |
| TLR4 | Toll-like receptor 4 | 1 | 0.501 |
| IL6 | Interleukin-6 | 1 | 0.342 |
| TLR2 | Toll-like receptor 2 | 1 | 0.292 |
| TLR9 | Toll-like receptor 9 | 1 | 0.200 |
| ADIPOQ | Adiponectin | −1 | −0.142 |