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Hypothetical regulation of Notch-Nrf2 crosstalk on oxidative stress amelioration. Hypothetical regulation of Notch-Nrf2 crosstalk was raised based on the results in this study. Arrows in red color represent the regulation by oxidized fish oil, in blue color represent the regulation by emodin under oxidized fish oil. “×” represents oxidized fish oil blocks the co-regulation between Notch and Nrf2 signaling.
