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Schematic flow-chart of T2DM model mice establishment and experimental drug administration. T2DM mice were established by feeding HFD daily for 10 weeks and injecting STZ intraperitoneally at the fourth week. Starting from week 5, mice were administered DL, DM, DH, DMBG for 6 weeks. Each group contained 10 mice. (ND: control feed; HFD: high fat feed; STZ: streptozocin; NS: normal saline; DL: YA 5 mg/kg; DM: YA 10 mg/kg; DH: YA 20 mg/kg; DMBG: metformin).
