Table 1.

Biological pathways (p < 0.001) and canonical functions (p < 0.01) that represent melanocytes’ dendritic cell-like (DC-like) or macrophage-like property. Networks which are perturbed by the toxins are double tick (√√) marked. In addition, the association of the networks with DC-like and/or macrophage-like properties are noted by single tick (√) mark.

Biological or Canonical Functions	Toxin			Biofunction Relevant to Which Melanocyte Character?
	SEA	TSST	SEB	DC-Like	Macrophage-Like
Early
Adhesion of blood cells	√√	√√		√	√
Antigen Presentation Pathway	√√	√√		√	√
Cdc42 Signalling	√√	√√		√
cell movement of leukocytes	√√	√√		√	√
cell movement of phagocytes	√√	√√		√	√
Chemokine Signaling		√√	√√		√
chemotaxis of phagocytes	√√			√	√
Complement System	√√			√	√
Crosstalk between Dendritic Cells and Natural Killer Cells	√√			√	√
Dendritic Cell Maturation	√√			√	√
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F	√√			√	√
ERK5 Signalling	√√				√
HMGB1 Signalling	√√			√	√
IL-17 Signalling	√√			√	√
IL-17A Signalling in Fibroblasts	√√			√
IL-8 Signalling	√√				√
Immune response of cells	√√			√	√
Immune response of leukocytes	√√			√	√
Immune response of phagocytes			√√	√	√
Inflammatory response			√√	√	√
MAPKKK cascade			√√	√	√
Migration of phagocytes	√√			√	√
Oxidative Phosphorylation	√√			√	√
PDGF Signalling	√√				√
Proliferation of immune cells	√√			√	√
synthesis of prostaglandin	√√			√
synthesis of prostaglandin E2	√√			√
T-cell lymphoproliferative disorder	√√			√	√
Late
Activation of blood cells	√√	√√		√	√
Adhesion of blood cells	√√	√√		√	√
Aggregation of blood cells	√√			√	√
Antigen Presentation Pathway	√√			√	√
Autophagy of cells	√√			√	√
Cell movement of connective tissue cells	√√				√
Cell movement of leukocytes	√√			√	√
Chemokine Signalling	√√			√	√
Chemotaxis of neutrophils	√√			√	√
Chemotaxis of phagocytes	√√			√	√
Complement System	√√			√	√
Crosstalk between Dendritic Cells and Natural Killer Cells	√√			√	√
Dendritic Cell Maturation	√√			√	√
Differentiation of hematopoietic progenitor cells	√√			√	√
eNOS Signalling	√√			√	√
IL-17 Signalling	√√			√	√
Immune response of cells	√√			√	√
Immune response of leukocytes	√√			√	√
Metabolism of eicosanoid	√√			√	√
Metabolism of prostaglandin			√√	√
Migration of antigen presenting cells			√√	√	√
Migration of phagocytes			√√	√	√
Phagosome Maturation			√√	√	√
PI3K/AKT Signalling		√√		√
Signalling by Rho Family GTPases		√√		√	√
Superoxide Radicals Degradation		√√		√	√
Synthesis of prostaglandin		√√		√
Transmigration of phagocytes		√√		√	√