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The “speed” by which CRCs and DMCRT reduces cell viability. CRCs manifested a threshold effect from 0.71–2.86 mg/mL, indicating that the induced cytotoxicity was time—independent (A). DMCRT manifested a dose-dependent “bell”-shaped behavior, with local maxima at 1.43 mg/mL, indicating that its effects were mostly time-dependent in all cases (B) (Legend: CRCs: Crocins, DMCRT: dimethylocrocetin).
