Figure 4.

Outlook on high-precision medical care, achieved by the profiling of isomiR. A recent study, using single-cell sequencing of various tissues, has provided links with data from liquid biopsy, such as that of peripheral blood. Given that the expression of isomiR-generating enzymes varies, according to the cell populations present in tissues, the study of isomiR will enable the detection of cell-specific expression patterns. This will improve the diagnosis of diseases, in which unique expression patterns are observed due to genomic and epigenomic variabilities, and will enable the development of precision medicine based on liquid biopsy analyses.