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. 2022 Jun 7;10(6):1345. doi: 10.3390/biomedicines10061345

Figure 1.

Figure 1

Figure 1

Figure 1

Increased TG2 levels were accompanied by pathological aggravation in UUO and 5/6 nephrected (Nx.) rodent models. UUO kidneys were evaluated thrice, on days 3, 7, and 14, after the establishment of the UUO model. (a) Representative images of UUO kidneys stained with Sirius red, immunohistochemical staining for TG2, and TUNEL assay on days 3, 7, and 14. (b) Semi-quantification results for Sirius red and TG2-stained UUO kidney. (c) Changes in TG2 mRNA abundance after 3, 7, and 14 days from UUO surgery. (d) Percentage of TUNEL positive area on days 3, 7, and 14. (e) In the 5/6 Nx. model, kidney tissue-expressed TG2 levels were evaluated twice at 4 and 8 weeks. Representative images of 5/6 Nx. kidneys stained with Sirius red, immunostained with TG2, and TUNEL assay. (f) Semi-quantification results for TG2-stained 5/6 Nx. Kidney. (g) Apoptosis was assessed twice at 4 and 8 weeks using the TUNEL assay. (Scale bar = 100μm, * p <0.05, ** p < 0.01, *** p < 0.001).