Table 2.
Characteristics of patients with TG2 expression in kidney tissue.
| Variable | Total (n = 94) |
IgAN (n = 56) |
DMN (n = 21) |
CTL (n = 17) |
p-Value | |||
|---|---|---|---|---|---|---|---|---|
| Group | IgAN vs. CTL | DMN vs. CTL | IgAN vs. DMN | |||||
| Age (year) | 44.95 ± 17.90 | 45.84 ± 15.16 | 47.24 ± 11.26 | 39.18 ± 17.90 | 0.205 | 0.133 | 0.099 | 0.702 |
| Sex (male, %) | 56 (56.57) | 36 (64.29) | 14 (66.67) | 6 (35.29) | 0.077 | |||
| BMI (kg/m2) | 23.75 ± 3.72 | 24.28 ± 3.12 | 25.04 ± 3.97 | 25.22 ± 4.00 | 0.694 | 0.514 | 0.927 | 0.476 |
| CKD stage 1, 2 (%) | 20 (35.71) | 5 (23.81) | ||||||
| CKD stage 3 (%) | 20 (35.71) | 9 (42.86) | ||||||
| CKD stage 4, 5 (%) | 16 (28.57) | 7 (33.33) | ||||||
| Blood hemoglobin (g/dL) | 12.26 ± 2.10 | 12.24 ± 2.00 | 11.44 ± 2.37 | 13.34 ± 1.68 | 0.019 | 0.043 | 0.008 | 0.141 |
| Serum albumin (g/dL) | 3.81 ± 0.59 | 3.85 ± 0.49 | 3.42 ± 0.77 | 4.14 ± 0.34 | <0.001 | 0.031 | 0.001 | 0.004 |
| Creatinine (mg/dL) | 1.56 ± 1.00 | 1.66 ± 0.99 | 1.95 ± 1.10 | 0.75 ± 0.17 | <0.001 | <0.001 | <0.001 | 0.259 |
| eGFR (CKD-EPI, mL/min/1.73 m2) | 64.26 ± 37.75 | 56.49 ± 33.39 | 50.51 ± 36.81 | 106.8 ± 19.39 | <0.001 | <0.001 | <0.001 | 0.498 |
| Urine protein/creatinine ratio | 2.42 ± 3.42 | 1.75 ± 2.17 | 5.77 ± 5.01 | 0.47 ± 0.30 | <0.001 | 0.019 | <0.001 | <0.001 |
| TG2 positive area (%) | 8.24 ± 5.61 | 10.26 ± 5.25 | 6.76 ± 5.72 | 3.39 ± 2.24 | <0.001 | <0.001 | 0.028 | 0.013 |
Values are means ± SD for continuous variables and n (%) for categorical variables. BMI: Body Mass Index.